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Several studies have shown that misfolded, mutant SOD1 disrupts redox homeostasis in ALS by the abnormal production of ROS and RNS, inducing oxidative stress (Poon et al., 2005

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Cyanocobalamin: Is the cheapest and most stable form of B12 and has a long shelf life but needs to have the cyanide molecule taken off, so has an extra conversion before being converted to methyl or adenyslcobalamin

Only scoring data submissions with all elements required for reporting in the Promoting Interoperability performance category should minimize the chance of MIPS eligible clinicians receiving a score of zero due to unintentional submissions