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Additionally, the synthetic capsaicin analog Arvanil induces high mitochondrial calcium flux, opening the mitochondrial membrane permeability transition pore (mPTP) and triggering ferroptosis in hepatocellular carcinoma (70)

Metabolites were separated on a Thermo Fisher Accucore TM -150-Amide-HILIC column (100 2.1 mm

Here, we report the development of a new viologen-based redox cycling agent, mito-diquat (Mito-DQ), capable of inducing targeted mitochondrial O 2 production at significantly higher rates as compared to previously reported mito-paraquat (Mito-PQ), a widely used chemical tool to study mitochondria-dependent redox signaling