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Med Clin North Am 96(2):269281 de Bruin TW, van Barlingen H, van Linde-Sibenius Trip M, van Vuurst de Vries AR, Akveld MJ, Erkelens DW

In summary, from modulating microglial polarization and neutralizing pro-inflammatory cytokines, to targeting immune checkpoints and astrocyte-derived inhibitory pathways, immunomodulatory strategies offer multifaceted approaches to disrupt the ferroptosisinflammation interplay

However, only pimitespib, an oral inhibitor developed by Taiho Pharmaceutical, was approved in Japan in 2022 for gastrointestinal stromal tumors, and it is currently the focus of a phase I study for the treatment of solid tumors in the EU and USA [7, 8]