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GHK-Cu is a reasonable alternative to maintain skin support during periods when vitamin A derivatives aren't suitable, though as always we'd suggest discussing with your healthcare provider if you're in any of these circumstances

Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway

this clinical finding has been reported previously

101 Ibotenic acid shares structural similarities with glutamate, an excitatory neurotransmitter, and is a potent N-methyl-D-aspartate receptor agonist, resulting in sustained activation and excitotoxicity