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In another study, rats with diabetic kidney disease (DKD) were treated with a CD38 inhibitor, resulting in increased renal NAD + levels, which in turn decreased mitochondrial oxidative stress 144

10.1016/j.cell.2007.03.024 Cell 39 BendottiC.TortaroloM.SuchakS

Furthermore, research on neural epithelial stem cells from LRRK2 -G2019S carriers indicates deregulated serine metabolism and proposes the SRR enzyme as a potential genetic modifier that could increase PD risk in LRRK2 -G2019S carriers (Nickels and Schwamborn, 2021)