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The Circular Life of Human CD38: From Basic Science to Clinics and Back

In the cecal ligation and puncture (CLP) paradigm, which simulates sepsis-induced ALI, luteolin treatment dramatically decreased lung inflammation, oxidative stress, and histological damage [96], followed by improvement in immune modulation by boosting Treg and IL-10 levels [255]

345,346,347 Altogether, obesity and IR play pivotal role in women with PCOS and subsequent metabolic complications, and targeting these areas may become an important therapeutic approach for effectively reducing incidence of this pathology