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J Exp Clin Cancer Res 44 , 180 (2025)

Future treatments should focus on pathway selectivity, possibly by aiming at upstream regulators, particular lysosomal channels like TPC2 in astrocytes, or distinct cargo receptors, that are unique to astrocytes or microglia, to distinguish between beneficial metabolic support and detrimental inflammatory activation

Furthermore, they reported a partial PROTAC library resulting from the ligation of small linkers with terminal benzaldehyde, which can subsequently react with hydrazide group in a 1:1 ratio thus forming acyl-hydrazone linkage PROTACs 129

However, it is believed to trigger apoptosis, or programmed cell death, in the sebaceous glands