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Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]

doi: 10.1038/s41598-022-13764-3 283 MarquardtVTheruvathJPauckDPicardDQinNBlmelLet al

This receptor-mediated upstream mechanism is the core distinction researchers cite when comparing Tesamorelin with fragment-based or mitochondrial-derived peptides

Journal of Clinical Biochemistry and Nutrition, 47 (3), 246-255