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Earlier lactate is considered a by-product of enhanced aerobic glycolysis and accumulated in malignant cells, raising the pH of the tumor microenvironment but a recent investigation by Brandon et al

Es spielt eine Schlsselrolle bei der Neutralisierung freier Radikale, der Regeneration anderer Antioxidantien (Vitamine C und E), der zellulren Entgiftung und der Beseitigung von Toxinen, der Aufrechterhaltung einer normalen Leber- und Immunsystemfunktion

Table 2 summarizes the key metabolic alterations observed in neurons, astrocytes, and microglia across major neurodegenerative diseases

First, in non-malignant tissues, PDK isoforms play essential physiological roles, particularly in highly energy-demanding organs such as the heart and skeletal muscle, where they regulate substrate utilization by limiting carbohydrate oxidation and promoting metabolic flexibility [190, 191]