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Both sites are located at the N-terminus, consistent with other reports 38,43

When CMS reconciles data due to an instance of agency error or manufacturer misreporting, we proposed that the agency will limit the scope of the reconciliation to the specific information that is the basis for the reconciliation and not update or otherwise revise any other data elements in the Rebate Report (set forth in 428.401(c)) or the report of the reconciled rebate amount (set forth in 428.401(d)) unless the correction directly impacts additional data fields

Secondary injury refers to further molecular and chemical inflammatory reactions such as blood hemoglobin and iron release, dysfunction of brain metabolism and cerebral blood flow, further triggering neuroinflammatory processes, oxidative stress, glutamatergic excitotoxicity and mitochondrial dysfunction, etc., which cause further brain damage (Stocchetti et al., 2017)

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