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The reasons for this are not entirely known

When the ER was first observed in chick embryonic cells by electron microscopy, it was simply described by Porter, Claude and colleagues as one of many submicroscopic cytoplasmic components ( Science article ( In particular, a number of proteins within the ER were discovered to be critical for the correct quality controlled folding and assembly of nascent glycoproteins these proteins were termed chaperones and included a wide array of unrelated protein families

2004;287(4):E591-601

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