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A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy

Genetic variations in genes such as interferon regulatory factor 5 (IRF5), TLR4, and vitamin D receptor (VDR) are linked to susceptibility across different populations [38,39,40,41,42], with specific SNPs like rs3807306 and rs4728142 associated with protective and risk factors, respectively [38]