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During sleep, the body undergoes essential repair processes, which include regenerating skin cells and reducing oxidative stress

doi: 10.1249/mss.0000000000002842 52 HuntRAliKBanhRBoldenMLaureaKMcBrideLet al

This includes the one-electron reduction of Dox into its semiquinone form by P450 reductase enzymes, two-electron reduction into the alcohol metabolite doxorubicinol by carbonyl reductase enzymes, reduction into doxorubicin 7-deoxyaglycone by the action of cytosolic NADPH-dependent glycosidases, and hydrolysis by NADPH-dependent microsomal oxidoreductases into doxorubicin hydroxyaglycone (Fig

For the DMM experiments, we decided to further increase our sample size for the preclinical setup as genetic recombination within adult articular cartilage may not be uniform between animals