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For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth

Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation

It demonstrated protective effects against chronic stress-induced physiological changes

For example, normally each time you reach overhead with your hand, your mind does not consciously have to think about doing the action, yet all of the muscles of the shoulder (and elbow, wrist, and upper back) coordinate the action just right so you can perform the movement without any discomfort or pinching