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Activation of microglia and astrocytes, along with increased central cytokine signaling, has been reported across mood episodes and may contribute to synaptic dysfunction and mood instability

Structure of GPX4 U46C is based on crystal structure reported in this work

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To precisely determine which site of the IGF1 promoter is responsible for ELF3 binding, each binding site was deleted from the IGF1 promoter to verify the site where ELF3 acts as a TF