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dsDNA can form PYD domain helical filament with AIM 2, nucleate ASC, mediate the activation of caspase-1, and induce the pyroptosis process or release active IL-1 and IL-18, which have great inflammatory potential (174)

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This leads to a decrease in migration and proliferation of cancer cells and sensitizes them into OX chemotherapy (Yin et al., 2019)

Preclinical Evidence Comparison Multiple independent preclinical and in vitro studies have confirmed the significant advantages of SAG in terms of bioavailability