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In contrast, a prospective, randomized clinical trial of 80 patients with advanced HCC treated with sorafenib plus metformin or sorafenib alone revealed that adding metformin to sorafenib did not improve treatment efficacy in patients with HCC [224]

doi: 10.1016/j.jaci.2013.04.035 45 BritesCGrassiMFQuaresmaJASIshakRVallinotoACR

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