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10.1016/j.jalz.2011.05.2410 234

These researches uncovered the key regulatory elements of the histone Kbhb pathway, laying the foundation for studying its role in different cellular processes

Clinical translation faces significant challenges: Despite compelling preclinical data, metabolic inhibitors have shown limited single-agent efficacy in clinical trials due to several factors: (1) dose-limiting toxicities affecting normal metabolically active tissues