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Molecular docking revealed hydrogen bonds with MPOs His95 and Arg239

Such coordinated signaling ensures rapid Ca 2+ uptake into the mitochondrial matrix, activation of TCA cycle enzymes, and stimulation of ATP synthesis ( 2+ fluctuations, promotes controlled secretion, and protects the cell from the spread of pathological calcium signals ( 2+ imaging, NADH autofluorescence, ATP sensors) rather than direct dynamic visualization of individual MAM microdomains, and thus cannot fully resolve the causality between structural contacts and functional responses

Iron accumulation-induced ROS, such as superoxide anion (O 2 -) and hydroxyl radical (OH), possess an unpaired electron at their outer orbit which allows them to react with all cellular components including proteins, lipids and nucleic acid

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