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[DOI] [PubMed] [Google Scholar] 615

The Innovation Medicine 3:100150

Germ-free mice showed increased bone mass, reduced CD4+ T cells and TNF- levels compared to normal counterparts, while FMT could restore these indexes to normal levels (117)

This is primarily relevant for HSC70 (Roperto, 2022), although BAG3 has also been shown to associate with HSPA1A, increasing its activity (Xia et al., 2025) or together with HSP70, as shown by Ruggiero and colleagues reporting the first known inhibitor targeting both BAG3HSP70 (Ruggiero et al., 2025)