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Besides inhibiting maconitase, zinc also induces apoptosis in prostate cancer cells via inhibition of NF-B, stimulation of caspases cascade, and induction of the cytochrome c from the mitochondria [87]

8-OHdG is produced when reactive oxygen species (ROS), specifically hydroxyl radicals, oxidize the guanine base in DNA, indicating oxidative DNA damage, that can be detected in circulation