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ART-induced mitochondrial toxicity with increased lactate to compete with uric acid excretion by the renal tubules and increased cell turnover followed by increased degradation of nucleotides accompanied by elevated uric acid in the serum were some of the possibilities by which uric acid is elevated in people living with HIV on HAART (6669)

Both cyanocobalamin and other forms of cobalamin can trigger these reactions, and the risk appears higher with parenteral (injection) administration compared to oral supplementation Khatrawi2022Sajan2023Ullah2018+1 MORE

Kompa, A

Not having a real excretion mechanism, it tends to accumulate in some vital organs such as the liver and kidneys