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For example, a meta-analysis of 15 RCTs of MedDiet interventions that measured obesity parameters in children and adolescents reported that the interventions had a significant effect on reducing BMI and obesity in this population ( To define biological pathways affected by components of the diet, studies using murine models and in vitro cultures can be quite valuable ( Cross-sectional studies examining adherence to the MedDiet and CRP concentrations found these to be inversely correlated ( As part of the CORDIOPREV (CORonary Diet Intervention with Olive oil and cardiovascular PREVention) prospective RCT, researchers suggest that the genetic variant of the NLRP3 inflammasome may modulate the benefits of the MedDiet ( 4 MedDiet and the gut microbiome Dietary patterns such as the Western diet and UPF consumption likely contribute to obesity partially through their impact on the gut microbiome

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