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While others felt the risks for using a device for a different indication than for which it was authorized by FDA, or using more than one device at a time could pose unknown risks and furthermore that similar efficacy could not be inferred for these use cases

A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies