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Neuroscience (2011) 185:97105.10.1016/j.neuroscience.2011.04.041 80 NguyenDAlaviMVKimK-YKangTScottRTNohYHet alA new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

Second messenger cascades can have long-term, widespread, and diverse cellular effects including activation of cellular enzymes or altering gene transcription