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Receptor proteins, that are found mostly, but not exclusively, on the surface of immune cells and epithelial cells, and bind to pathogen- associated molecular patterns (PAMPs) triggering host cell signals that lead to the secretion of cytokines and activation of the innate immune response

Although more studies are needed to further elucidate the processes involved, it has been shown that oxidative damage of cardiomyocytes and DNA leads to cell dysfunction and apoptosis which in turn leads to electrical instability and prolonged refractory periods seen clinically on the ECG as conduction disease (49, 57)

BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia