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In the CCI model, cuminaldehyde not only alleviated allodynia and hyperalgesia at doses ranging from 25 to 100 mg/kg, but it also significantly decreased serum levels of the inflammatory cytokines TNF- and IL-1 (Koohsari et al., 2020)

The utilization of bioactive compounds from natural sources remains an important area of research, given the urgent need for safe and non-resistant drugs

study found that delivering miR-494-3p via a PLGA nanoparticle-hydrogel system significantly enhanced Achilles tendon healing in rats by sustainedly releasing miR-494-3p into tenocytes, where it suppressed CXXC4 translation, activated collagen I synthesis, improved biomechanical strength, and reduced inflammation (Wang G

Heparin is often exploited as a natural polymer, as many pro-angiogenic proteins contain heparin-binding domains