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W.MarigowdaG.HuangX.CipolliM.et al

Peripheral low-grade inflammation exacerbates this effect by diverting tryptophan metabolism (usually a precursor for serotonin) toward the KYN pathway, resulting in reduced peripheral tryptophan availability and lower central serotonin synthesis (24) (Figure 11)

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Similar content being viewed by others Introduction Almost all animals display a wide range of circadian rhythms in behaviour and physiology, such as locomotor activity, sleep, learning and memory, mating and endocrine function 1,2,3,4