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Description

Clarke et al., 2013

Increased gut permeability in first-degree relatives of children with irritable bowel syndrome or functional abdominal pain

Sorafenib blocks systemic XC-mediated cystine input, causing endoplasmic reticulum stress, GSH depletion, and iron-dependent lipid ROS buildup (114)

Abnormal immune activation, genetic susceptibility, and environmental influences have each been implicated as critical determinants of disease initiation and progression