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specific epigenetic modifications (e.g., DNA methylation and histone acetylation) that regulate ferroptosis-related genes (e.g., GPX4 and SLC7A11) in LN immune cells or renal tissue have not been systematically mapped

The concomitant impact aging has on astrocytes also induces a phenotypic switch that results in altered gene expression, perpetuation of inflammation, and recruitment of peripheral immune cells, which further exacerbates inflammation (Palmer and Ousman, 2018

Innate immune stimulation may contribute to the formation and/or maintenance of the TRM pool, ensuring rapid recall of CD8 + T cell responses upon challenge