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Anti-IL-23p19 antibodies, such as risankizumab, guselkumab, brazikumab, and mirikizumab, have also demonstrated efficacy and favorable safety profiles [317, 318]

The duration of fermentation, which ranges between five and 14 days, also determines the concentrations of acid, ethanol, and vitamins, which subsequently dictate whether the drink will taste tart or have stronger vinegar undertones

Moreover, compromised intestinal barrier integrity and gut-derived microbial components such as LPS activate TLR/NF-B/NLRP3 pathways, which not only drive systemic inflammation but also modulate gut-derived tryptophan metabolism and serotonin synthesis, thereby coupling immune regulation with neuromodulatory functions

Exome sequencing and SNP microarray (Illumina 654k) were performed on participant DNA