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GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols

Long-term use of medications like proton pump inhibitors (PPIs) and metformin[16], which can reduce B12 absorption

The RDA only tells you the minimum amount needed to avoid deficiency in most healthy people

143 This regulation occurs through mitochondrial membrane potential (m)-dependent mechanisms, as NLRP3 inflammasome activation requires m oscillations that are intrinsically linked to circadian rhythms