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This reaction can be combined with strain-promoted azide-alkyne click (SPAAC) and inverse-electron-demand DielsAlder (iEDDA) reactions to achieve dual functionalization of proteins in a sequential simple one-pot reaction

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Safety and efficacy of flavonoid compounds in dogs and cats is lacking, but a safety study of green tea extract (a type of flavonoid supplement) in healthy beagles showed a high morbidity and mortality rate, prompting early termination of the study 24