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Shammas M, Edward C, Sarkar J, et al

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

42:10 Dr

PBMC isolation Peripheral blood was collected in EDTA-containing tubes and PBMCs were isolated using SepMate-50 tubes according to the manufacturers protocol (STEMCELL Technologies)