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Acknowledgements This work was supported by a grant from the National Natural Science Foundation of China (No

Similar content being viewed by others Introduction Ferroptosis is an iron-dependent, regulated cell death, which is different from apoptosis, necrosis and autophagy and is characterized by the accumulation of lipid peroxides in cells [1]

16 The metabolic disorders cause a variety of complications

Naturally occurring antioxidant defense mechanisms might be either enzymatic (dismutase superoxide, catalase, and glutathione peroxidase) or non-enzymatic (uric acid, ascorbic acid, bilirubin, albumin, flavonoids, -tocopherol, ubiquinol and carotenoids) [2, 4, 5]