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However, high levels of IGFBP-3 in breast tumor tissues are associated with increased xenograft growth in mice and poor prognosis

1 Introduction Chronic kidney disease (CKD) represents a progressive disorder marked by ongoing kidney damage or a diminished glomerular filtration rate that persists for more than 3 months ( According to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines, CKD-MBD is a systemic syndrome characterized by abnormalities in bone histology and ectopic calcification