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[Accessed 27 Oct.2025] (online) Ema.omeprazole

These pathways are coordinated by S-adenosylmethionine (SAM), which have a specific role as an allosteric inhibitor for the methylenetetrahydrofolate reductase (MTHFR) reaction and acts as an activator of cystathionine -synthase (CBS) [2]

Glutamine anaplerosis supplies glutamate, while the transsulfuration pathway provides cysteinethe rate-limiting precursor for GSH biosynthesis [57, 97]

Cases were stratified by CSs to study association with overall (OS) and disease-free (DFS) survival distinctions via Kaplan-Meier analyses and gene expression distinctions via Pearsons correlation