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Fibrinogen promotes atherosclerosis by increasing inflammation, inducing expression of immune cell adhesion molecules on blood vessel surfaces, and stimulating vascular smooth muscle cell migration and proliferation

Although this treatment option might benefit ME/CFS treatment [82, 83], only two studies on ClinicalTrials.gov explore this, despite theories linking microbiota to the diseases progression [12, 84]

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MelAutim evaluated adverse events and quality of life in patients with melanoma treated mainly with anti-PD-1 and anti-CTLA-4 monoclonal antibodies 70,71