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doi: 10.1124/jpet.108.142208

This process is dependent on ubiquitination and phosphorylation, which are regulated by specific ubiquitin E3 ligase and NIK-IKK axis, respectively

When using hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuing CYP3A4 inhibitors, follow patients at frequent intervals and consider increasing the opioid dosage if needed to maintain adequate analgesia or if symptoms of opioid withdrawal occur (see PRECAUTIONS, Drug Interactions)