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In summary, it appears that mitochondria are altered in BD, even before clinical symptoms arise

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157,158,159,160 Histone methyltransferases are closely related to drug resistance (Fig

M.SamborskaB.et al

At the transcriptome level, genes encoding enzymes involved in the pentose phosphate pathway, NADK , NADK2 , G6PD , PGLS , PGD , and TALDO1 were up-regulated with BDG exposure in a GSH-dependent manner ( Figures 6D I and Supplementary Figure 4 )