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Overall, glutathiones therapeutic applications with documented outcomes include: (1) chemotherapy neuroprotection (robust RCT evidence), (2) dermatologic pigmentation and skin property modulation (multiple RCTs with modest effects), (3) exploratory use in PD (pilot and ongoing/complete trials), (4) modulation of oxidative stress and immune function biomarkers with formulation-dependent efficacy, and (5) biomarker effects in ASD without symptom data

Flippo KH, Trammell SA, Gillum MP, Aklan I, Perez MB, Yavuz Y, et al

The CXCR2, a G protein coupled receptor, is involved in a series of leukocyte cellular responses, such as cell recruitment and migration ( Figure 1 ) (Jones et al., 1997

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