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Mukherji A, Kobiita A, Ye T, Chambon P

Both epidermis-specific Mll4- knockout mice and Alox12b loss-of-function mutant mice exhibited epidermal hyperproliferation, scaling, and other cutaneous manifestations similar to ichthyosis, as well as a deficiency of ALOX12b expression in the epidermis of both mice

28 Half-Life and Steady State If the dose of a drug that is administered is greater than the dose that is eliminated during the dosing interval, it will take about 5 half-lives for a drug to reach steady state levels

The targeted delivery of neuroprotective agents across the BBB is mainly attributed to their increased drug-loading capacity and controlled release mechanisms