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Goiter: the pathophysiology of many conditions and the mechanisms of gland dysfunction, such as the abnormal enlargement of the thyroid gland called goiter, can be induced experimentally in animal models

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Oxidative Stress The concept of oxidative stress has developed from the free radical theory of oxygen toxicity developed in the 1950s with studies such as those by Rebecca Gerschman showing that oxygen poisoning and X-irradiation can both produce oxygen-derived free radicals [35,36]

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