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However trilostane is the only medication licensed for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism (Cushing's disease and syndrome) in dogs and is largely considered as a safe and effective drug for managing both PDH and ADH (Schofield et al 2021)

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It is one potentially modifiable biochemical burden that may coexist with methylation imbalance, oxidative stress, copper-zinc dysregulation, pyroluria, gut dysfunction or immune activation

Its mechanism of treating RA mainly involves these aspects: anti-inflammation, anti-oxidation, immune regulation, pro-apoptosis, inhibition of angiogenesis, inhibition of osteoclastogenesis, inhibition of fibroblast-like synovial cell proliferation, migration and invasion