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A description of the study rationale, design, and methods is given elsewhere [34]

135,136,137 Moreover, Badgley et al

Nevertheless, current nucleic acid methods exhibit representatively the restricted sensitivity for living cell imaging and intracellular analysis 29,30,31

These include: Renal impairment impaired kidneys cannot clear excess magnesium and other minerals safely G6PD deficiency high-dose vitamin C can trigger haemolytic anaemia in these patients Congestive heart failure fluid overload risk with IV administration