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Only reads that uniquely mapped to the reference sequence chr17: 34,283,17334,286,052 of the Homo sapiens genome (Gencode, release 38) were considered for the methylation analysis

The limitations of conventional TRT become apparent when you consider: Testicular atrophy from prolonged external testosterone use Potential cardiovascular risks in certain populations Suppression of natural hormone production pathways Limited impact on other declining hormones like growth hormone Potential fertility issues in younger men This is where the comparison between peptide therapy for men and traditional approaches becomes compelling

Recently, Raj et al

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