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LFB staining revealed that the myelin sheath in the corpus callosum was clear, and the microtubules in the axons were tightly arranged in the vitamin B12+4-PBA group relative to vitamin B12 treatment group (Figure 5E)

The importance of this has been demonstrated when Tomas et al

In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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