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Thus, these data suggested that 2-DG interfere with normal proIGF-1Ea glycosylation process leading to an accumulation of an under-glycosylated form which is still able to fold and secreted by the cells

Individuals with active cancer or a history of malignancy should avoid the peptide unless under medical supervision, as effects on tumor growth have not been adequately studied

How long this phase lasts depends on how bad the deficiency is and how well the patient responds

The presence of the alternative Eb- and Ec-domains hampers the proIGF-1Eb and proIGF-1Ec sensitivity to N-glycosylation inhibitors and determines the nuclear accumulation of prohormones The proIGF-1Eb and proIGF-1Ec ran at the expected molecular weight of ~16.5 kDa and ~12.5 kDa in SDS-PAGE gels respectively, suggesting that these prohormones did not undergo posttranslational modification (Supplementary Fig