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Studies assessing animal motor activity in the open field revealed effects of 6-OHDA lesions on total distance traveled by the animals, accompanied by a significant decrease in motor activity, as well as notable reductions in movement initiation in rats exposed to 6-OHDA (Carvalho et al., 2013

After 6 weeks, the gene-modified group exhibited improved toughness, maximal load to failure, and organized collagen bundles compared to controls ( Collectively, these studies highlight the significant therapeutic potential of IGF-1 in tendon healing across various animal models