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This cellular energy crisis directly manifests as the profound physical fatigue, "brain fog," and post-exertional malaise (PEM) that patients experience

Biochem J 391:185190 Wakabayashi H, Wakabayashi M, Eisenreich W, Engel KH (2004) Stereochemical course of the generation of 3-mercaptohexanol by -lyase-catalyzed cleavage of cysteine conjugates